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24 Similarly, Gosha-jinki-gan (GJG), a Japanese herbal medicine, with the expression of the transient receptor potential melastatin 8 (TRPM8) and transient receptor potential ankyrin 1 (TRPA1) channels is well-known for its effectiveness in minimizing symptoms of peripheral neuropathy by suppressing the overexpression of TRPM8 and TRPA1 mRNA
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Also, intracellular ROS is produced by a variety of enzymes, including cyclooxygenases (COXs), nitric oxide synthase (NOS), myeloperoxidase (MPO), glucose oxidase, xanthine oxidase (XO), NADPH oxidase (NOX), and peroxidases
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